Abstract: With the construction and commissioning of major hydropower projects represented by Baihetan of Jinsha River, it is of great significance to clarify the mechanical and seepage characteristics of engineering rock mass under complex stress environment with high confining pressure and high water pressure. Based on the field survey data and the structural characteristics of the columnar jointed basalt of dam foundation, two kinds of columnar joint similar material model samples with different dip angles β, quadrangular prisms and hexagonal prisms, are prepared, and the true triaxial stress-seepage coupling tests are carried out. The test results show that the columnar jointed rock mass with different cross-section characteristics has strong permeability anisotropy, and the permeability coefficient k is positively correlated with β at different loading stages. During the true triaxial loading process, the volume strain ε_V of the sample can be used as an effective characterization parameter of k. At the volume compression stage, k shows a low level, and at the volume expansion stage k shows a rapid growth trend. The final failure mode of the samples exhibits three typical forms, and the most dangerous failure mode is the structural failure dominated by the shear slip failure of the joint surface, which mainly occurs in the samples with β=45°, 60°. Correspondingly, the lateral support of this kind of rock mass should be strengthened in the construction design of surrounding rock of tunnels and rock mass of dam foundation.